Tag Archives: IIT Guwahati

IIT-Guwahati develops advanced nanotechnology for cholesterol, triglyceride detection

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The institute claims that their researchers have focused on a technique that combines nanotechnology and molecular detection, which can further be translated into a point-of-care as device with an enhanced diagnostic precision.

Researchers at Indian Institute of Technology (IIT), Guwahati have developed an innovative approach to improve the detection of cholesterol and triglycerides by integrating Surface-Enhanced Raman Scattering (SERS) on the nanoscale objects, officials said.

The findings of the research were recently published in the noted journal –Biosensors and Bioelectronics.

According to Dipankar Bandyopadhyay, Professor at Centre for Nanotechnology and Department of Chemical Engineering, IIT-Guwahati, the work utilises bimetallic nanostructures that are 10,000 times thinner than the width of a human hair for the high-fidelity detection of the biomarkers in the human blood.

“The metabolic biomolecules like cholesterol and triglycerides play pivotal role in maintaining a harmonious cardiovascular health of a human body. The high (HDL) and low (LDL) density lipoproteins transport cholesterol to the cellular sites for various metabolic activities,” he said.

Bandyopadhyay explained an imbalance of LDL and HDL causes arterial plaque formation leading to hypertension, formation of blood clots, or ischemia.

On the other hand, triglycerides (TGA) transform into fatty acids and glycerol during digestion which in turn is packaged inside lipoproteins namely very low-density lipoprotein (VLDL), for transportation to the cells. An elevated level of triglycerides leads to atherosclerosis and coronary artery disease, pancreatitis, type 2 diabetes, or fatty liver, he said.

“Therefore, the timely detection of any abnormality and a close monitoring of cholesterol and triglyceride levels in blood is highly sought for. While traditional lipid profile tests of blood are reliable, they often require laboratory settings, are not available as a point-of-care solution, and can take time to provide results,” he said.

IIT-Guwahati claimed that their researchers have focused on a technique that combines nanotechnology and molecular detection, which can further be translated into a point-of-care as device with an enhanced diagnostic precision.

“The researchers employ SERS active bimetallic nanostructures – the silver shelled gold nanorods, which enable a plasmonic resonance hybridisation of silver and gold to produce augmented spectral resolutions as compared to pristine silver or gold nanorods.

“Subsequently, these bimetallic nanorods are linked to two different Raman active receptors and immobilised with the enzymes cholesterol oxidase and lipase for concurrent detection of different concentrations of cholesterol and triglycerides. Such innovations help in the development of a platform for the ultrafast point-of-care detection kit with a higher level of the detection sensitivity,” Bandyopadhyay said.

Except for the headline, this story has not been edited by The Telegraph Online staff and has been published from a syndicated feed.

source/content: telegraphindia.com (headline edited)


Researchers from the Indian Institute of Technology Guwahati and the Bose Institute Kolkata have developed an advanced injectable hydrogel for localised cancer treatment.

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This innovative hydrogel-based therapy delivers anti-cancer drugs directly to tumour sites, reducing side effects associated with cancer treatments.

Researchers from the Indian Institute of Technology Guwahati and the Bose Institute Kolkata have developed an advanced injectable hydrogel for localised cancer treatment.

This innovative hydrogel-based therapy delivers anti-cancer drugs directly to tumour sites, significantly reducing side effects typically associated with conventional cancer treatments.

The findings have been published in the “Materials Horizons”, a journal of the Royal Society of Chemistry. The paper is co-authored by Prof Debapratim Das, along with research scholars Tanushree Das and Ritvika Kushwaha from IIT Guwahati. The collaborators are Dr Kuldip Jana, Satyajit Halder and Anup Kumar Misra from the Bose Institute Kolkata.

“Cancer continues to be a pressing global health challenge, with millions of patients affected worldwide. Current treatments, such as chemotherapy and surgical interventions, often have severe limitations. Surgical removal of tumors is sometimes not feasible, particularly for internal organs, while chemotherapy’s systemic delivery often results in harmful side effects by affecting both cancerous and healthy cells,” the IIT Guwahati said in a statement.

Prof Das from the Department of Chemistry and his team addressed these challenges by designing a hydrogel that delivers drugs precisely to the tumour site, ensuring localised action.

Hydrogels are water-based, three-dimensional polymer networks capable of absorbing and retaining fluids. Their unique structure mimics living tissues, making them suitable for biomedical applications. This newly developed hydrogel acts as a stable reservoir for anti-cancer drugs and releases them in a controlled manner, responding to specific conditions in the tumour microenvironment.

The hydrogel, composed of ultra-short peptides – biocompatible and biodegradable building blocks of proteins – is designed to remain insoluble in biological fluids, ensuring it stays localized at the injection site. It responds to elevated glutathione (GSH) levels, a molecule abundant in tumour cells. Upon encountering high GSH levels, the hydrogel triggers a controlled drug release directly into the tumour, minimizing its interaction with healthy tissues and reducing systemic side effects.

Speaking about the breakthrough, Prof Das said, “This work exemplifies how scientific innovation can directly address the pressing needs of cancer treatment. The hydrogel’s unique properties allow it to work in harmony with the biological environment, offering precision where it is needed most. We are excited by its potential to transform our thoughts about localized drug delivery.”

In pre-clinical trials on a murine model of breast cancer, the hydrogel showcased remarkable efficacy. A single injection of the hydrogel, loaded with the chemotherapy drug doxorubicin, resulted in a 75% reduction in tumour size within 18 days. Crucially, the hydrogel remained localized at the tumour site, steadily releasing the drug over time without causing detectable side effects on other organs, the IIT Guwahati said.

“This innovative delivery system enhances the drug’s effectiveness while reducing the required dosage, thus minimizing toxicity. Laboratory studies further demonstrated that the hydrogel improves drug uptake by cancer cells, induces cell cycle arrest, and promotes programmed cell death, thereby attacking tumours on multiple fronts,” the institute further stated.

source/content: newindianexpress.com (headline edited)


NATIONAL: HEALTH & MEDICAL SCIENCES: INNOVATION: IIT-Guwahati researchers develop solutions based on Regenerative Therapies for Knee Tears

IT-G has created three hydrogel formulations that are blends of silk fibroin and other polymers, which can be used by doctors in clinics, to treat the meniscus injury.

Researchers at the Indian Institute of Technology- (IIT) Guwahati, in collaboration with University of Animal and Fishery Sciences, Kolkata, has formulated three treatment solutions for a knee injury that has proven difficult to treat.

By developing these key regenerative therapies, the researchers have provided possible alternative solutions to manage the problem of a knee meniscus tear, an injury to tissue in one’s knee joints, the IIT-G said in a release.

“We have developed regenerative treatment approaches that would be tailored for the patient and help in rapid healing meniscus tears or replacing parts of the damaged tissue,” Professor Biman B Mandal, department of biosciences and bioengineering, IIT-G, said.

Trauma to the knee meniscus, a cushioning tissue in the knee joint, is a common yet complex problem. A tear in the tissue can make it difficult to walk, run or perform daily activities.

The 3 hydrogels

The IIT-G team has created three hydrogel formulations that are blends of silk fibroin and other polymers, which can be used by doctors in clinics, to treat the meniscus injury.

These components, especially silk, are well known for their strength, bioactivity and flexibility. They are also cost-effective compared to other materials such as commercially available polyurethane and collagen meniscus implants, the release said.

Out of the three, one is an injectable hydrogel, which can be injected in a minimally invasive manner directly into the meniscus site to expedite the healing of smaller injuries.

For treating larger full thickness complex meniscus tissue injuries, the researchers have created two 3D bio-printable inks that can be 3D printed into implants.

In the two bioink formulations, one carries commercially available growth factor loaded microspheres, the second carries patient derived factors which are released in a sustained manner aiding faster meniscus healing. Both formulations can be 3D printed into a partial or full sized meniscus and used for healing large portions of the meniscus.

3D printing, or bioprinting, has recently emerged as a popular futuristic method for tissue engineering. Here, the implant is customized as per the patient’s requirements.

The research aims to provide a more personalised and effective treatment for meniscus injuries, potentially improving the quality of life for millions of people.

The developments signal a significant advancement, providing solutions custom-made for each patient and could also potentially prevent future complications such as osteoarthritis.

The three approaches have been published in three manuscripts in international journals Applied Materials Today and Advanced Biology, co-authored by Mandal and his team of research scholars — Ashutosh Bandyopadhyay, Baishali Ghibhela, and Sayanti Shome and Dr Debajyoti Pal, Dr Samsamul Hoque and Professor Samit K Nandi from the University of Animal and Fishery Sciences.

source/content: moneycontrol.com (headline edited)